Now we’re on to something 🙂

So I decided to ask Chat GPT a more specific question, which genes are involved in white cell formation,

got a much more interesting answer–

Remember when I did Neupogen shots, and how for the first time in my life I had a white cell count in the 20s?

I remember that day, because it taught me that my body knows how to make white cells,

it’s just not doing it when it’s supposed to — there’s a trigger in the communication chain that isn’t working —

(Besides how it’s inherited, it’s not skipping a generation, another reason I feel this is a dominate gene, one gene is working okay and the other is not, which is why there is a partial response –)

Anyhow, Noah and I got to go someone who knows how to make sense of what this Chat GPT answer came up with — I really don’t understand enough about the immune system or genes, but I recognize some of the wording here and I feel like this is getting close to the problem —

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Question I asked Chat GPT:

What genes are involved in generate white blood cells

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Answer:

Several genes play a crucial role in the generation and functioning of white blood cells. Here are some key genes associated with white blood cell development and function:

1. GATA1: This gene is involved in the development of various blood cell lineages, including white blood cells. It plays a role in the differentiation and maturation of megakaryocytes, erythrocytes (red blood cells), and some types of white blood cells, such as eosinophils and basophils.
2. GATA2: Mutations in this gene can lead to a condition called GATA2 deficiency, which affects the production and function of several types of white blood cells, including monocytes, dendritic cells, and natural killer cells. GATA2 is crucial for the development of these cell types in the bone marrow.
3. CSF3R: This gene encodes the receptor for granulocyte colony-stimulating factor (G-CSF), a cytokine that regulates the production and differentiation of neutrophils, a type of white blood cell. Mutations in CSF3R can cause severe congenital neutropenia, a condition characterized by a reduced number of neutrophils in the blood. [This one I want to explore, given how I had a strong response to the Neupon shots, like the shot gave my body a tool that it’s in short supply]
4. RAG1 and RAG2: These genes encode the proteins responsible for V(D)J recombination, a process that enables the generation of diverse antigen receptors in lymphocytes, including B cells and T cells. Mutations in RAG1 or RAG2 can result in severe combined immunodeficiency (SCID), a condition where both T and B cell function is impaired.
5. IKZF1: This gene is involved in the development of lymphocytes, including B cells and certain types of T cells. Mutations in IKZF1 have been associated with a predisposition to acute lymphoblastic leukemia (ALL), a cancer of the white blood cells.
6. CEBPA: This gene encodes a transcription factor that regulates the development and maturation of myeloid cells, including certain types of white blood cells like granulocytes and monocytes. Mutations in CEBPA can disrupt the differentiation of these cells, leading to disorders such as acute myeloid leukemia (AML).

These are just a few examples of genes involved in the generation and function of white blood cells. The development and regulation of white blood cells are complex processes involving multiple genes and signaling pathways.